# The Chicago Consensus on peritoneal surface malignancies: management of appendiceal neoplasms

Source: https://onco.cc/key-papers/paper-chicago-consensus-appendiceal-neoplasms-cancer-2020/  
OnCo record `paper-chicago-consensus-appendiceal-neoplasms-cancer-2020` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A multidisciplinary consensus laying out treatment pathways for each kind of appendix tumour, from low-grade mucinous neoplasms to adenocarcinoma and goblet cell adenocarcinoma, including when cytoreductive surgery with heated chemotherapy and when systemic chemotherapy are appropriate.

## Summary

Consensus from the Chicago Consensus Working Group of surgical, medical and pathological oncologists giving management algorithms for appendiceal neoplasms: LAMN with and without peritoneal disease, high-grade mucinous neoplasm, mucinous and non-mucinous adenocarcinoma, and goblet cell adenocarcinoma.

It recommends cytoreductive surgery with HIPEC for peritoneal disease in centres with expertise, systemic chemotherapy based on colorectal regimens for high-grade and adenocarcinoma histologies, and observation for low-grade disease confined to the appendix.

## Fields

- Kind: Key paper
- Last checked: 2026-09-18
- Journal: Cancer
- Year: 2020
- DOI: 10.1002/cncr.32881
- Authors: Chicago Consensus Working Group.
- What it means: The standard-of-care rows on the appendiceal pages, particularly who is referred for cytoreductive surgery and who receives chemotherapy, follow this consensus and the NCCN appendiceal section.
- Caveats: Consensus on limited retrospective evidence; no randomised trial has tested chemotherapy in appendiceal adenocarcinoma at the time of writing.; Applies to centres with peritoneal surface malignancy expertise.

## Sources

- Cancer 2020: https://doi.org/10.1002/cncr.32881
- PubMed: https://pubmed.ncbi.nlm.nih.gov/32282073/

## Connected records

- cancers: [Appendiceal adenocarcinoma (mucinous and non-mucinous, including signet ring cell)](https://onco.cc/cancers/appendiceal-adenocarcinoma/), [Goblet cell adenocarcinoma of the appendix](https://onco.cc/cancers/goblet-cell-adenocarcinoma/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Mitomycin C](https://onco.cc/drugs/mitomycin/)
- journals: [Cancer](https://onco.cc/journals/cancer-wiley/)

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