# Use of the Xpert Bladder Cancer Monitor Urinary Biomarker Test for Guiding Cystoscopy in High-grade Non-muscle-invasive Bladder Cancer: Results from the Randomized Controlled DaBlaCa-15 Trial

Source: https://onco.cc/key-papers/paper-dreyer-xpert-bladder-dablaca-15-eur-urol-2025/  
OnCo record `paper-dreyer-xpert-bladder-dablaca-15-eur-urol-2025` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A Danish randomised trial in which a urine RNA test was used to decide when people under bladder cancer follow-up needed a camera examination of the bladder.

## Summary

1,029 cystoscopies were performed in the control arm and 445 in the intervention arm. The risk difference for high-grade recurrence was 0.08 per cent (95% CI minus 7.2 to 7.4), and two pTa high-grade recurrences were missed.

## Fields

- Kind: Key paper
- Last checked: 2026-11-04
- Journal: European Urology
- Year: 2025
- DOI: 10.1016/j.eururo.2025.03.018
- Authors: Dreyer T, Brandt S, Fabrin K, et al.
- Findings: Cystoscopies 1,029 (control) against 445 (test-guided).; High-grade recurrence risk difference 0.08% (95% CI -7.2 to 7.4).
- What it means: A urine RNA test cut camera examinations by more than half in this trial, with two missed recurrences.
- Caveats: Wide confidence interval for recurrence.

## Sources

- Dreyer et al., Eur Urol 2025: https://doi.org/10.1016/j.eururo.2025.03.018
- PubMed: https://pubmed.ncbi.nlm.nih.gov/40280776/

## Connected records

- cancers: [Non-muscle-invasive bladder cancer](https://onco.cc/cancers/non-muscle-invasive-bladder-cancer/)
- fronts: [Diagnostics & Biomarkers](https://onco.cc/fronts/diagnostics/)
- technologies: [Liquid RNA biopsy (cell-free, vesicle and platelet RNA)](https://onco.cc/technologies/liquid-rna-biopsy/), [Urine tests for bladder cancer (cytology, FISH, RNA and methylation)](https://onco.cc/technologies/urine-bladder-cancer-tests/)
- drugs: [Xpert Bladder Cancer Monitor](https://onco.cc/drugs/xpert-bladder-cancer-monitor/)
- terms: [Biomarker](https://onco.cc/terms/biomarker/)

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