# EAU-ASCO collaborative guideline on penile cancer, 2023 update

Source: https://onco.cc/key-papers/paper-eau-asco-penile-cancer-guideline-eur-urol-2023/  
OnCo record `paper-eau-asco-penile-cancer-guideline-eur-urol-2023` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The joint European and American guideline for penile cancer, from HPV testing and organ-sparing surgery to sentinel node biopsy, lymph node surgery and chemotherapy for node-positive disease.

## Summary

Collaborative guideline from the European Association of Urology and the American Society of Clinical Oncology covering diagnosis, HPV and p16 testing, penile-preserving treatment (topical therapy, laser, glansectomy, partial penectomy), management of the groin nodes with dynamic sentinel node biopsy or inguinal lymphadenectomy, neoadjuvant and adjuvant chemotherapy for node-positive disease, radiotherapy, follow-up and sexual and psychological support.

It grades the evidence, most of which is retrospective, and recommends referral to centralised centres and enrolment in trials such as InPACT.

## Fields

- Kind: Key paper
- Last checked: 2026-09-18
- Journal: European Urology
- Year: 2023
- DOI: 10.1016/j.eururo.2023.02.027
- Authors: Brouwer OR, Albersen M, Parnham A, et al.
- What it means: The standard-of-care entries on the penile cancer pages, from keeping as much of the penis as is safe to staging the groins with a sentinel node procedure, follow this guideline.
- Caveats: Almost all recommendations rest on retrospective series; randomised evidence in penile cancer is limited to the InPACT trial.; Access to dynamic sentinel node biopsy is limited to specialised centres.

## Sources

- Eur Urol 2023: https://doi.org/10.1016/j.eururo.2023.02.027
- PubMed: https://pubmed.ncbi.nlm.nih.gov/36906413/

## Connected records

- cancers: [Localised penile cancer (organ-confined, node-negative)](https://onco.cc/cancers/localised-penile-cancer/), [Node-positive and metastatic penile cancer](https://onco.cc/cancers/node-positive-penile-cancer/)
- journals: [European Urology](https://onco.cc/journals/european-urology/)

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