# Oncogenic EGFR signaling networks in glioma

Source: https://onco.cc/key-papers/paper-egfr-glioblastoma-sci-signal-2009/  
OnCo record `paper-egfr-glioblastoma-sci-signal-2009` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Review on EGFR in Glioma & glioblastoma, in Science signaling (2009), one of the most cited Europe PMC records with EGFR in its title.

## Summary

The epidermal growth factor receptor (EGFR) is a primary contributor to glioblastoma (GBM) initiation and progression. Here, we examine how EGFR and key downstream signaling networks contribute to the hallmark characteristics of GBM such as rapid cancer cell proliferation and diffused invasion. Additionally, we discuss current therapeutic options for GBM patients and elaborate on the mechanisms through which EGFR promotes chemoresistance. We conclude by offering a perspective on how the potential of integrative systems biology may be harnessed to develop safe and effective treatment strategies for this disease.

Indexed on Europe PMC as PubMed record 19738203 (DOI 10.1126/scisignal.287re6). Its title names EGFR and its text names Glioma & glioblastoma; PubMed types it as a review (Review). It was matched automatically to the idea "Attack extrachromosomal DNA, the engine of oncogene amplification" and no figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Science signaling
- Year: 2009
- DOI: 10.1126/scisignal.287re6
- Authors: Huang PH, Xu AM, White FM
- What it means: One of the most cited reviews Europe PMC returns for EGFR in Glioma & glioblastoma, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
- Caveats: Matched by EGFR in the title and Glioma & glioblastoma in the title or abstract of the Europe PMC record; the summary reproduces the record's abstract and no figure has been verified against the full paper.; A review summarises other studies; the primary reports it cites are the evidence.

## Sources

- Sci Signal 2009: https://doi.org/10.1126/scisignal.287re6
- PubMed: https://pubmed.ncbi.nlm.nih.gov/19738203/
- Europe PMC: https://europepmc.org/article/MED/19738203

## Connected records

- ideas: [Attack extrachromosomal DNA, the engine of oncogene amplification](https://onco.cc/ideas/idea-ecdna-targeting/), [Focused-ultrasound BBB opening to deliver ADCs and radioligands to glioma](https://onco.cc/ideas/idea-fus-plus-adc-glioma/)

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