# Eribulin versus dacarbazine in previously treated advanced liposarcoma or leiomyosarcoma

Source: https://onco.cc/key-papers/paper-eribulin-liposarcoma-schoffski-lancet-2016/  
OnCo record `paper-eribulin-liposarcoma-schoffski-lancet-2016` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Eribulin lengthened survival by two months compared with dacarbazine in previously treated liposarcoma and leiomyosarcoma, with the entire benefit in liposarcoma, where survival improved by seven months, leading to its approval for that subtype.

## Summary

Phase 3 trial of 452 patients with advanced liposarcoma or leiomyosarcoma after at least two prior regimens randomised to eribulin or dacarbazine.

Median overall survival was 13.5 versus 11.5 months (hazard ratio 0.77) overall, and 15.6 versus 8.4 months in liposarcoma (hazard ratio 0.51) with no difference in leiomyosarcoma; progression-free survival was similar between arms.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: The Lancet
- Year: 2016
- DOI: 10.1016/S0140-6736(15)01283-0
- Authors: Schöffski P, Chawla S, Maki RG, et al.
- Findings: Median overall survival 13.5 vs 11.5 months overall; hazard ratio 0.77.; Liposarcoma: 15.6 vs 8.4 months; hazard ratio 0.51.
- What it means: Eribulin is an approved later-line treatment for liposarcoma, one of the few sarcoma drugs with a demonstrated survival benefit.
- Caveats: No progression-free survival benefit, an unusual pattern.; Dacarbazine is an active comparator in leiomyosarcoma.

## Sources

- Lancet 2016: https://doi.org/10.1016/S0140-6736(15)01283-0
- PubMed: https://pubmed.ncbi.nlm.nih.gov/26874885/

## Connected records

- cancers: [Liposarcoma](https://onco.cc/cancers/liposarcoma/)
- drugs: [Dacarbazine](https://onco.cc/drugs/dacarbazine/), [Eribulin](https://onco.cc/drugs/eribulin/)
- journals: [The Lancet](https://onco.cc/journals/lancet/)

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