# ESGO/ESTRO/ESP guidelines for the management of endometrial carcinoma (2021)

Source: https://onco.cc/key-papers/paper-esgo-estro-esp-endometrial-concin-ijgc-2021/  
OnCo record `paper-esgo-estro-esp-endometrial-concin-ijgc-2021` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The European gynaecological oncology, radiotherapy and pathology societies' joint guideline integrates molecular classification into risk groups for endometrial cancer and sets adjuvant treatment for each, including no adjuvant therapy for early POLE-mutated tumours.

## Summary

Joint evidence-based guideline covering diagnosis, molecular classification, surgical staging including sentinel node mapping, risk group definitions incorporating molecular class, adjuvant radiotherapy and chemotherapy recommendations, fertility-sparing treatment, and management of advanced and recurrent disease.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: International journal of gynecological cancer
- Year: 2021
- DOI: 10.1136/ijgc-2020-002230
- Authors: Concin N, Matias-Guiu X, Vergote I, et al.
- What it means: The adjuvant recommendations on this site's endometrial subtype pages (observation for stage I to II POLE-mutated disease, chemotherapy for p53-abnormal tumours with myometrial invasion, brachytherapy for intermediate risk) follow this guideline.
- Caveats: Some molecular-based de-escalation recommendations await confirmation from the RAINBO trials.

## Sources

- Int J Gynecol Cancer 2021: https://doi.org/10.1136/ijgc-2020-002230
- PubMed: https://pubmed.ncbi.nlm.nih.gov/33397713/

## Connected records

- cancers: [Endometrial cancer with no specific molecular profile](https://onco.cc/cancers/endometrial-nsmp/), [POLE-ultramutated endometrial cancer](https://onco.cc/cancers/endometrial-pole-ultramutated/)
- journals: [International journal of gynecological cancer](https://onco.cc/journals/international-journal-of-gynecological-cancer/)

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