# Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan clinical practice guideline

Source: https://onco.cc/key-papers/paper-esmo-bone-sarcoma-guideline-strauss-ann-oncol-2021/  
OnCo record `paper-esmo-bone-sarcoma-guideline-strauss-ann-oncol-2021` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The European guideline for bone sarcomas covers referral to specialist centres, biopsy, surgery, chemotherapy for osteosarcoma and Ewing sarcoma, and the surgery-based management of chondrosarcoma and chordoma including proton and carbon-ion radiotherapy.

## Summary

Joint European guideline on the diagnosis, treatment and follow-up of bone sarcomas in adults and children, with sections on osteosarcoma, Ewing sarcoma, chondrosarcoma (including atypical cartilaginous tumour, dedifferentiated and mesenchymal subtypes), chordoma and giant cell tumour of bone.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: Annals of Oncology
- Year: 2021
- DOI: 10.1016/j.annonc.2021.08.1995
- Authors: Strauss SJ, Frezza AM, Abecassis N, et al.
- What it means: The chondrosarcoma page's recommendations for curettage of low-grade limb lesions, wide resection for higher grades and particle therapy for skull base tumours follow this guideline.
- Caveats: Evidence for chemotherapy in dedifferentiated and mesenchymal chondrosarcoma remains weak.

## Sources

- Ann Oncol 2021: https://doi.org/10.1016/j.annonc.2021.08.1995
- PubMed: https://pubmed.ncbi.nlm.nih.gov/34500044/

## Connected records

- cancers: [Chondrosarcoma](https://onco.cc/cancers/chondrosarcoma/)
- journals: [Annals of Oncology](https://onco.cc/journals/annals-of-oncology/)

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