# Non-epithelial ovarian cancer: ESMO clinical practice guidelines

Source: https://onco.cc/key-papers/paper-esmo-non-epithelial-ovarian-ray-coquard-ann-oncol-2018/  
OnCo record `paper-esmo-non-epithelial-ovarian-ray-coquard-ann-oncol-2018` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The ESMO guideline on the rarer ovarian cancers, including granulosa cell and other sex cord-stromal tumours and germ cell tumours, sets out surgery, when chemotherapy is needed, fertility preservation and long-term follow-up.

## Summary

Evidence-based guideline covering diagnosis, staging, surgical management including fertility-sparing surgery, adjuvant and recurrent-disease chemotherapy, hormonal therapy and follow-up for malignant germ cell tumours and sex cord-stromal tumours of the ovary.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: Annals of Oncology
- Year: 2018
- DOI: 10.1093/annonc/mdy001
- Authors: Ray-Coquard I, Morice P, Lorusso D, et al.
- What it means: The observation after complete surgery for stage I granulosa cell tumour, lifelong inhibin monitoring and endocrine or bevacizumab-based options at relapse follow this guideline.
- Caveats: Evidence in sex cord-stromal tumours is largely retrospective.

## Sources

- Ann Oncol 2018: https://doi.org/10.1093/annonc/mdy001
- PubMed: https://pubmed.ncbi.nlm.nih.gov/29697741/

## Connected records

- cancers: [Adult granulosa cell tumour of the ovary](https://onco.cc/cancers/granulosa-cell-tumour/)
- journals: [Annals of Oncology](https://onco.cc/journals/annals-of-oncology/)

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