# Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS clinical practice guideline

Source: https://onco.cc/key-papers/paper-esmo-sts-guideline-gronchi-ann-oncol-2021/  
OnCo record `paper-esmo-sts-guideline-gronchi-ann-oncol-2021` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The European sarcoma guideline sets out referral to reference centres, biopsy and molecular diagnosis, surgery with radiotherapy for localised disease, the selective use of chemotherapy, and histology-driven treatment of advanced disease.

## Summary

Joint European guideline covering the diagnosis, staging, multidisciplinary management and follow-up of soft tissue and visceral sarcomas in adults, including limb and trunk sarcomas, retroperitoneal sarcoma, gastrointestinal stromal tumour, desmoid tumours and subtype-specific systemic therapy recommendations.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: Annals of Oncology
- Year: 2021
- DOI: 10.1016/j.annonc.2021.07.006
- Authors: Gronchi A, Miah AB, Dei Tos AP, et al.
- What it means: The general principles on the sarcoma subtype pages (reference centre surgery, radiotherapy for high-grade deep tumours, doxorubicin first line, histology-directed later lines) follow this guideline.
- Caveats: Updated periodically; drug approvals since 2021 (for example nab-sirolimus, afamitresgene) are not covered.

## Sources

- Ann Oncol 2021: https://doi.org/10.1016/j.annonc.2021.07.006
- PubMed: https://pubmed.ncbi.nlm.nih.gov/34303806/

## Connected records

- cancers: [Leiomyosarcoma](https://onco.cc/cancers/leiomyosarcoma/), [Liposarcoma](https://onco.cc/cancers/liposarcoma/), [Malignant peripheral nerve sheath tumour (MPNST)](https://onco.cc/cancers/malignant-peripheral-nerve-sheath-tumour/), [Myxofibrosarcoma](https://onco.cc/cancers/myxofibrosarcoma/), [Perivascular epithelioid cell tumour (PEComa)](https://onco.cc/cancers/pecoma/), [Retroperitoneal sarcoma](https://onco.cc/cancers/retroperitoneal-sarcoma/), [Soft tissue sarcoma of the extremity (localised and advanced)](https://onco.cc/cancers/extremity-soft-tissue-sarcoma/), [Undifferentiated pleomorphic sarcoma (UPS)](https://onco.cc/cancers/undifferentiated-pleomorphic-sarcoma/)
- journals: [Annals of Oncology](https://onco.cc/journals/annals-of-oncology/)

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