# FIGO staging for gestational trophoblastic neoplasia 2000

Source: https://onco.cc/key-papers/paper-figo-2000-staging-gestational-trophoblastic-neoplasia-ijgo-2002/  
OnCo record `paper-figo-2000-staging-gestational-trophoblastic-neoplasia-ijgo-2002` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The FIGO Oncology Committee's system that combines an anatomical stage with a prognostic score to split gestational trophoblastic neoplasia into low-risk disease, cured with a single drug, and high-risk disease needing combination chemotherapy.

## Summary

Report of the FIGO Oncology Committee setting out the FIGO 2000 classification of gestational trophoblastic neoplasia: anatomical stages I to IV (uterus, pelvis and adnexa, lungs, other metastases) combined with the modified WHO prognostic scoring system based on age, antecedent pregnancy, interval, hCG level, tumour size, site and number of metastases and prior failed chemotherapy.

A score of 6 or less defines low-risk disease, treated with single-agent methotrexate or dactinomycin, and 7 or more high-risk disease, treated with multi-agent regimens such as EMA/CO. The system replaced several competing schemes and remains in use.

## Fields

- Kind: Key paper
- Last checked: 2026-09-18
- Journal: International Journal of Gynecology & Obstetrics
- Year: 2002
- DOI: 10.1016/S0020-7292(02)00063-2
- Authors: FIGO Oncology Committee.
- What it means: Whether a woman with GTN receives one drug or several rests on this scoring system, which is why OnCo has separate low-risk and high-risk pages.
- Caveats: The score was derived from historical series and some elements (such as blood group in earlier versions) were dropped for practicality.; Women with scores of 5 to 6 or with choriocarcinoma often fail single-agent therapy, and some centres treat them more intensively.

## Sources

- Int J Gynaecol Obstet 2002: https://doi.org/10.1016/S0020-7292(02)00063-2
- PubMed: https://pubmed.ncbi.nlm.nih.gov/12065144/

## Connected records

- cancers: [High-risk gestational trophoblastic neoplasia (FIGO score 7 or more, including ultra-high-risk)](https://onco.cc/cancers/high-risk-gtn/), [Low-risk gestational trophoblastic neoplasia (FIGO score 0 to 6)](https://onco.cc/cancers/low-risk-gtn/)

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