# Intensified therapies improve survival and identification of novel prognostic factors for placental-site and epithelioid trophoblastic tumours

Source: https://onco.cc/key-papers/paper-froeling-pstt-ett-intensified-therapy-bjc-2019/  
OnCo record `paper-froeling-pstt-ett-intensified-therapy-bjc-2019` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

An updated UK series of placental-site and epithelioid trophoblastic tumours found that more intensive treatment, including high-dose chemotherapy for the worst-prognosis women, improved survival, and refined the factors that predict outcome.

## Summary

Retrospective analysis of 125 women with placental-site or epithelioid trophoblastic tumour treated in the UK trophoblastic disease centres, extending the earlier Charing Cross series.

Survival improved in the later period with intensified platinum-based chemotherapy and, for women with an interval of 48 months or more since the antecedent pregnancy, high-dose chemotherapy with stem cell rescue; stage, interval and other factors such as hCG level and metastatic pattern were prognostic.

## Fields

- Kind: Key paper
- Last checked: 2026-09-18
- Journal: British Journal of Cancer
- Year: 2019
- DOI: 10.1038/s41416-019-0402-0
- Authors: Froeling FEM, Ramaswami R, Papanastasopoulos P, et al.
- Findings: Survival improved in the more recent treatment era with intensified therapy.; Interval of 48 months or more from the antecedent pregnancy remained the dominant adverse factor, with high-dose chemotherapy offering some long-term survivors.
- What it means: Women with poor-prognosis placental-site or epithelioid trophoblastic tumours should be referred to a specialist centre where intensified and experimental treatments, including immunotherapy, are available.
- Caveats: Retrospective, with treatment changing over time.; Small numbers in the high-dose chemotherapy group.

## Sources

- Br J Cancer 2019: https://doi.org/10.1038/s41416-019-0402-0
- PubMed: https://pubmed.ncbi.nlm.nih.gov/30792530/

## Connected records

- cancers: [Placental-site trophoblastic tumour and epithelioid trophoblastic tumour](https://onco.cc/cancers/placental-site-trophoblastic-tumour/)
- drugs: [Cisplatin](https://onco.cc/drugs/cisplatin/), [Etoposide](https://onco.cc/drugs/etoposide/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/)
- journals: [British Journal of Cancer](https://onco.cc/journals/british-journal-of-cancer/)

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