# The threat of medical misinformation: a case of ivermectin toxicity in a pediatric oncology patient

Source: https://onco.cc/key-papers/paper-gilene-ivermectin-toxicity-paediatric-oncology-2025/  
OnCo record `paper-gilene-ivermectin-toxicity-paediatric-oncology-2025` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A letter describing severe ivermectin poisoning in a young patient with bone cancer who was also taking regorafenib, a cancer drug that shares the enzyme ivermectin is cleared by.

## Summary

Europe PMC indexes this letter without an abstract, so OnCo transcribes no figures from it (Gilene paediatric case 2025). The ICONIC trial's registry entry summarises it as a case of severe neurotoxicity in a patient with metastatic osteosarcoma receiving regorafenib, likely due to a pharmacokinetic interaction through CYP3A4 (ClinicalTrials.gov NCT07487805).

## Fields

- Kind: Key paper
- Last checked: 2026-09-24
- Journal: Pediatric Blood & Cancer
- Year: 2025
- DOI: 10.1002/pbc.31876
- Authors: Gilene S, Haacker L, Rutan H, Pressey JG.
- Findings: Severe neurotoxicity in a paediatric osteosarcoma patient on regorafenib, attributed to a CYP3A4 interaction, as summarised by the ICONIC registry entry.
- What it means: A reminder that ivermectin interacts with cancer drugs: the dose that a healthy adult tolerates can poison a patient whose liver enzymes are already occupied by a kinase inhibitor.
- Caveats: Letter with no indexed abstract; details are taken from the ICONIC registry's summary of it.

## Sources

- Gilene paediatric case 2025: https://doi.org/10.1002/pbc.31876
- PubMed: https://pubmed.ncbi.nlm.nih.gov/40556334/
- ClinicalTrials.gov NCT07487805: https://clinicaltrials.gov/study/NCT07487805

## Connected records

- cancers: [Osteosarcoma](https://onco.cc/cancers/osteosarcoma/)
- drugs: [Ivermectin](https://onco.cc/drugs/ivermectin/), [Regorafenib](https://onco.cc/drugs/regorafenib/)
- terms: [Pharmacokinetics (PK), half-life and exposure](https://onco.cc/terms/pharmacokinetics/)
- trials: [ICONIC: ivermectin combined with immune checkpoint inhibition in cancer (University of Florida phase 2)](https://onco.cc/trials/nct07487805/)
- bottlenecks: [Misinformation and unproven therapies](https://onco.cc/bottlenecks/b-misinformation/)
- journals: [Pediatric Blood & Cancer](https://onco.cc/journals/pediatric-blood-and-cancer/)

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