# DNA-encoded chemistry: enabling the deeper sampling of chemical space

Source: https://onco.cc/key-papers/paper-goodnow-nat-rev-drug-discov/  
OnCo record `paper-goodnow-nat-rev-drug-discov` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one technology page, indexed on Europe PMC as PubMed record 27932801 and published in Nature Reviews Drug Discovery; the citing page links this DOI, which is how the record was matched.

## Summary

DNA-encoded chemical library technologies are increasingly being adopted in drug discovery for hit and lead generation. DNA-encoded chemistry enables the exploration of chemical spaces four to five orders of magnitude more deeply than is achievable by traditional high-throughput screening methods. Operation of this technology requires developing a range of capabilities including aqueous synthetic chemistry, building block acquisition, oligonucleotide conjugation, large-scale molecular biological transformations, selection methodologies, PCR, sequencing, sequence data analysis and the analysis of large chemistry spaces. This Review provides an overview of the development and applications of DNA-encoded chemistry, highlighting the challenges and future directions for the use of this technology.

Indexed on Europe PMC as PubMed record 27932801 (DOI 10.1038/nrd.2016.213). Matched by DOI alone: one technology page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Nature Reviews Drug Discovery
- Year: 2017
- DOI: 10.1038/nrd.2016.213
- Authors: Goodnow RA, Dumelin CE, Keefe AD
- What it means: One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Nat Rev Drug Discov 2017: https://doi.org/10.1038/nrd.2016.213
- PubMed: https://pubmed.ncbi.nlm.nih.gov/27932801/
- Europe PMC: https://europepmc.org/article/MED/27932801

## Connected records

- technologies: [High-throughput screening and DNA-encoded libraries](https://onco.cc/technologies/high-throughput-screening-libraries/)
- journals: [Nature Reviews Drug Discovery](https://onco.cc/journals/nature-reviews-drug-discovery/)

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