# Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Source: https://onco.cc/key-papers/paper-greten-immunity/  
OnCo record `paper-greten-immunity` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one pathway page, indexed on Europe PMC as PubMed record 31315034 and published in Immunity; the citing page links this DOI, which is how the record was matched.

## Summary

Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage in well-orchestrated reciprocal interactions to form an inflammatory tumor microenvironment (TME). Cells within the TME are highly plastic, continuously changing their phenotypic and functional characteristics. Here, we review the origins of inflammation in tumors, and the mechanisms whereby inflammation drives tumor initiation, growth, progression, and metastasis. We discuss how tumor-promoting inflammation closely resembles inflammatory processes typically found during development, immunity, maintenance of tissue homeostasis, or tissue repair and illuminate the distinctions between tissue-protective and pro-tumorigenic inflammation, including spatiotemporal considerations. Defining the cornerstone rules of engagement governing molecular and cellular mechanisms of tumor-promoting inflammation will be essential for further development of anti-cancer therapies.

Indexed on Europe PMC as PubMed record 31315034 (DOI 10.1016/j.immuni.2019.06.025). Matched by DOI alone: one pathway page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Immunity
- Year: 2019
- DOI: 10.1016/j.immuni.2019.06.025
- Authors: Greten FR, Grivennikov SI
- What it means: One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Immunity 2019: https://doi.org/10.1016/j.immuni.2019.06.025
- PubMed: https://pubmed.ncbi.nlm.nih.gov/31315034/
- Europe PMC: https://europepmc.org/article/MED/31315034

## Connected records

- pathways: [Inflammation & NF-κB](https://onco.cc/pathways/inflammation-nfkb/)

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