# Lung Master Protocol (Lung-MAP)-A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400

Source: https://onco.cc/key-papers/paper-herbst-clin-cancer-res/  
OnCo record `paper-herbst-clin-cancer-res` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one trial page, indexed on Europe PMC as PubMed record 25680375 and published in Clinical Cancer Research; the citing page links this DOI, which is how the record was matched.

## Summary

The Lung Master Protocol (Lung-MAP, S1400) is a groundbreaking clinical trial designed to advance the efficient development of targeted therapies for squamous cell carcinoma (SCC) of the lung. There are no approved targeted therapies specific to advanced lung SCC, although The Cancer Genome Atlas project and similar studies have detected a significant number of somatic gene mutations/amplifications in lung SCC, some of which are targetable by investigational agents. However, the frequency of these changes is low (5%-20%), making recruitment and study conduct challenging in the traditional clinical trial setting. Here, we describe our approach to development of a biomarker-driven phase II/II multisubstudy "Master Protocol," using a common platform (next-generation DNA sequencing) to identify actionable molecular abnormalities, followed by randomization to the relevant targeted therapy versus standard of care.

Indexed on Europe PMC as PubMed record 25680375 (DOI 10.1158/1078-0432.ccr-13-3473). Matched by DOI alone: one trial page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Clinical Cancer Research
- Year: 2015
- DOI: 10.1158/1078-0432.ccr-13-3473
- Authors: Herbst RS, Gandara DR, Hirsch FR, et al.
- What it means: One trial page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Clin Cancer Res 2015: https://doi.org/10.1158/1078-0432.ccr-13-3473
- PubMed: https://pubmed.ncbi.nlm.nih.gov/25680375/
- Europe PMC: https://europepmc.org/article/MED/25680375

## Connected records

- trials: [Lung-MAP (SWOG S1400 and S1900)](https://onco.cc/trials/lung-map/)
- journals: [Clinical Cancer Research](https://onco.cc/journals/clinical-cancer-research/)

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