# The JAK/STAT signaling pathway: from bench to clinic

Source: https://onco.cc/key-papers/paper-hu-signal-transduct-target-ther/  
OnCo record `paper-hu-signal-transduct-target-ther` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one pathway page, indexed on Europe PMC as PubMed record 34824210 and published in Signal transduction and targeted therapy; the citing page links this DOI, which is how the record was matched.

## Summary

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.

Indexed on Europe PMC as PubMed record 34824210 (DOI 10.1038/s41392-021-00791-1). Matched by DOI alone: one pathway page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Signal transduction and targeted therapy
- Year: 2021
- DOI: 10.1038/s41392-021-00791-1
- Authors: Hu X, Li J, Fu M, et al.
- What it means: One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Signal Transduct Target Ther 2021: https://doi.org/10.1038/s41392-021-00791-1
- PubMed: https://pubmed.ncbi.nlm.nih.gov/34824210/
- Europe PMC: https://europepmc.org/article/MED/34824210

## Connected records

- pathways: [JAK-STAT signalling](https://onco.cc/pathways/jak-stat/)

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