# Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia

Source: https://onco.cc/key-papers/paper-jain-cancer-cell/  
OnCo record `paper-jain-cancer-cell` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one term page, indexed on Europe PMC as PubMed record 25517747 and published in Cancer Cell; the citing page links this DOI, which is how the record was matched.

## Summary

Ten antiangiogenic drugs targeting VEGF or its receptors are approved for cancer treatment. However, these agents, intended to block tumors' blood supply, may cause hypoxia, which may fuel tumor progression and treatment resistance. Emerging clinical data suggest that patients whose tumor perfusion or oxygenation increases in response to these agents may actually survive longer. Hence, strategies aimed at alleviating tumor hypoxia while improving perfusion may enhance the outcome of radiotherapy, chemotherapy, and immunotherapy. Here I summarize lessons learned from preclinical and clinical studies over the past decade and propose strategies for improving antiangiogenic therapy outcomes for malignant and nonmalignant diseases.

Indexed on Europe PMC as PubMed record 25517747 (DOI 10.1016/j.ccell.2014.10.006). Matched by DOI alone: one term page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Cancer Cell
- Year: 2014
- DOI: 10.1016/j.ccell.2014.10.006
- Authors: Jain RK
- What it means: One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Cancer Cell 2014: https://doi.org/10.1016/j.ccell.2014.10.006
- PubMed: https://pubmed.ncbi.nlm.nih.gov/25517747/
- Europe PMC: https://europepmc.org/article/MED/25517747

## Connected records

- terms: [Mechanical theory: stiffness, pressure and force as causes](https://onco.cc/terms/mechanical-theory-of-cancer/)
- journals: [Cancer Cell](https://onco.cc/journals/cancer-cell/)

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