# Clonal hematopoiesis in human aging and disease

Source: https://onco.cc/key-papers/paper-jaiswal-science/  
OnCo record `paper-jaiswal-science` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one term page, indexed on Europe PMC as PubMed record 31672865 and published in Science; the citing page links this DOI, which is how the record was matched.

## Summary

As people age, their tissues accumulate an increasing number of somatic mutations. Although most of these mutations are of little or no functional consequence, a mutation may arise that confers a fitness advantage on a cell. When this process happens in the hematopoietic system, a substantial proportion of circulating blood cells may derive from a single mutated stem cell. This outgrowth, called "clonal hematopoiesis," is highly prevalent in the elderly population. Here we discuss recent advances in our knowledge of clonal hematopoiesis, its relationship to malignancies, its link to nonmalignant diseases of aging, and its potential impact on immune function. Clonal hematopoiesis provides a glimpse into the process of mutation and selection that likely occurs in all somatic tissues.

Indexed on Europe PMC as PubMed record 31672865 (DOI 10.1126/science.aan4673). Matched by DOI alone: one term page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Science
- Year: 2019
- DOI: 10.1126/science.aan4673
- Authors: Jaiswal S, Ebert BL
- What it means: One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Science 2019: https://doi.org/10.1126/science.aan4673
- PubMed: https://pubmed.ncbi.nlm.nih.gov/31672865/
- Europe PMC: https://europepmc.org/article/MED/31672865

## Connected records

- terms: [Ageing tissue and clonal fields: cancer as a disease of old tissue](https://onco.cc/terms/ageing-tissue-field-theory/)
- journals: [Science](https://onco.cc/journals/science/)

---
JSON: https://onco.cc/api/v1/entities/paper-jaiswal-science.json