# Japanese gastric cancer treatment guidelines 2021 (6th edition)

Source: https://onco.cc/key-papers/paper-japanese-gastric-cancer-treatment-guidelines-2021-gastric-cancer-2023/  
OnCo record `paper-japanese-gastric-cancer-treatment-guidelines-2021-gastric-cancer-2023` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The Japanese Gastric Cancer Association guideline sets the criteria for endoscopic resection, the extent of gastrectomy and lymph node dissection, adjuvant chemotherapy by stage and systemic therapy for advanced disease, and is the reference for early gastric cancer worldwide.

## Summary

Sixth edition of the Japanese guideline covering absolute and expanded indications for endoscopic submucosal dissection, eCura assessment of curability, surgical procedures and D1+ or D2 lymphadenectomy, laparoscopic and robotic surgery, adjuvant S-1-based chemotherapy, perioperative therapy, and first- to third-line systemic therapy for unresectable disease.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: Gastric cancer
- Year: 2023
- DOI: 10.1007/s10120-022-01331-8
- Authors: Japanese Gastric Cancer Association.
- What it means: The early gastric cancer page's endoscopic criteria and surgical recommendations follow this guideline.
- Caveats: Adjuvant and advanced-disease recommendations reflect Japanese practice (S-1) and differ from Western guidelines.

## Sources

- Gastric Cancer 2023: https://doi.org/10.1007/s10120-022-01331-8
- PubMed: https://pubmed.ncbi.nlm.nih.gov/36342574/

## Connected records

- cancers: [Early gastric cancer](https://onco.cc/cancers/early-gastric-cancer/)
- journals: [Gastric cancer](https://onco.cc/journals/gastric-cancer/)

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