# Systemic therapy in the palliative management of advanced salivary gland cancers (review)

Source: https://onco.cc/key-papers/paper-laurie-licitra-salivary-systemic-jco-2006/  
OnCo record `paper-laurie-licitra-salivary-systemic-jco-2006` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

This review of chemotherapy in salivary gland cancers concluded that responses are uncommon and short, that observation is reasonable for slowly progressing disease, and that trials of targeted agents based on tumour biology were needed.

## Summary

Systematic review of systemic therapy studies in recurrent or metastatic salivary gland carcinoma, summarising response rates to single agents and combinations by histology, the natural history of indolent adenoid cystic carcinoma, and early experience with targeted agents.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: Journal of Clinical Oncology
- Year: 2006
- DOI: 10.1200/JCO.2005.05.3025
- Authors: Laurie SA, Licitra L.
- What it means: The observation-first approach for indolent metastases and the move to biomarker-directed therapy (HER2, androgen receptor, NTRK) on the salivary cancer pages follow this review's conclusions.
- Caveats: Predates the HER2, androgen receptor and immunotherapy studies that now guide treatment.

## Sources

- J Clin Oncol 2006: https://doi.org/10.1200/JCO.2005.05.3025
- PubMed: https://pubmed.ncbi.nlm.nih.gov/16763282/

## Connected records

- cancers: [Adenoid cystic carcinoma](https://onco.cc/cancers/adenoid-cystic-carcinoma/), [Mucoepidermoid carcinoma](https://onco.cc/cancers/mucoepidermoid-carcinoma/), [Salivary duct carcinoma](https://onco.cc/cancers/salivary-duct-carcinoma/)
- journals: [Journal of Clinical Oncology](https://onco.cc/journals/jco/)

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