# MonumenTAL-1: talquetamab, a GPRC5D-directed bispecific antibody for relapsed multiple myeloma

Source: https://onco.cc/key-papers/paper-monumental-1-talquetamab-nejm-2022/  
OnCo record `paper-monumental-1-talquetamab-nejm-2022` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Talquetamab, an antibody that pulls T cells onto a new myeloma target called GPRC5D, produced responses in about seven in ten heavily pretreated patients, including those already treated with BCMA-directed therapy.

## Summary

Phase 1 dose-escalation and expansion study of 288 patients with relapsed or refractory multiple myeloma treated with subcutaneous talquetamab at 405 micrograms per kilogram weekly or 800 micrograms per kilogram every two weeks.

Response rates were about 70 percent at both doses with a median duration of response of about 10 months; cytokine release syndrome was common but mostly low grade, and skin, nail and taste changes were characteristic.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: New England Journal of Medicine
- Year: 2022
- DOI: 10.1056/NEJMoa2204591
- Authors: Chari A, Minnema MC, Berdeja JG, et al.
- Findings: Overall response about 70 percent at the two recommended doses.; Median duration of response roughly 10 months; cytokine release syndrome in about three quarters, mostly grade 1 to 2.
- What it means: A second bispecific target beyond BCMA gives patients an option after BCMA-directed CAR-T or bispecifics have failed; it was approved in 2023.
- Caveats: Single-arm early-phase data.; Dysgeusia, weight loss and skin toxicity affect quality of life and adherence.

## Sources

- N Engl J Med 2022: https://doi.org/10.1056/NEJMoa2204591
- PubMed: https://pubmed.ncbi.nlm.nih.gov/36507686/

## Connected records

- cancers: [Relapsed or refractory multiple myeloma](https://onco.cc/cancers/myeloma-relapsed-refractory/)
- drugs: [MCLA-129](https://onco.cc/drugs/mcla-129/), [Talquetamab](https://onco.cc/drugs/talquetamab/)
- trials: [MonumenTAL-1](https://onco.cc/trials/monumental-1/)
- journals: [New England Journal of Medicine](https://onco.cc/journals/nejm/)

---
JSON: https://onco.cc/api/v1/entities/paper-monumental-1-talquetamab-nejm-2022.json