# Myxofibrosarcoma: clinicopathological analysis of 75 cases with emphasis on the low-grade variant

Source: https://onco.cc/key-papers/paper-myxofibrosarcoma-mentzel-ajsp-1996/  
OnCo record `paper-myxofibrosarcoma-mentzel-ajsp-1996` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

This series defined myxofibrosarcoma as a distinct sarcoma of elderly limbs with characteristic curvilinear blood vessels and a strong tendency to recur locally and progress in grade, features that still guide its wide excision.

## Summary

Clinicopathological study of 75 cases of myxofibrosarcoma establishing diagnostic criteria (multinodular growth, myxoid stroma, curvilinear vessels, pleomorphic cells), a grading spectrum from low to high grade, a local recurrence rate of about 50 to 60 percent often with grade progression, and metastasis mainly from high-grade tumours.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: American Journal of Surgical Pathology
- Year: 1996
- DOI: 10.1097/00000478-199604000-00001
- Authors: Mentzel T, Calonje E, Wadden C, et al.
- Findings: Local recurrence in over half of cases regardless of grade, with progression to higher grade in a proportion.; Metastasis mostly from intermediate- and high-grade tumours.
- What it means: The recognition that myxofibrosarcoma infiltrates along tissue planes far beyond the visible mass underlies the wide, MRI-planned excision and adjuvant radiotherapy recommended today.
- Caveats: Retrospective pathology series.

## Sources

- Am J Surg Pathol 1996: https://doi.org/10.1097/00000478-199604000-00001
- PubMed: https://pubmed.ncbi.nlm.nih.gov/8604805/

## Connected records

- cancers: [Myxofibrosarcoma](https://onco.cc/cancers/myxofibrosarcoma/)

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