# Biliary Tract Cancers, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology

Source: https://onco.cc/key-papers/paper-nccn-biliary-tract-cancers-v2-2025-jnccn-2025/  
OnCo record `paper-nccn-biliary-tract-cancers-v2-2025-jnccn-2025` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The 2025 summary of the US NCCN guideline for gallbladder and bile duct cancers, focused on what to give after surgery.

## Summary

Journal summary of the NCCN Guidelines for Biliary Tract Cancers, version 2.2025, which cover gallbladder cancer, intrahepatic and extrahepatic cholangiocarcinoma. The panel meets at least yearly to review requests and new data; this manuscript focuses on the adjuvant chemotherapy and chemoradiation recommendations. The 2023 Insights paper (Benson et al., JNCCN 2023, PMID 37433432) recorded the split of the former Hepatobiliary Cancers guideline into separate Hepatocellular Carcinoma and Biliary Tract Cancers guidelines.

## Fields

- Kind: Key paper
- Last checked: 2026-09-24
- Tags: gallbladder-evidence
- Journal: Journal of the National Comprehensive Cancer Network
- Year: 2025
- DOI: 10.6004/jnccn.2025.0042
- Authors: Benson AB, D'Angelica MI, Abrams T, et al.
- Findings: Covers gallbladder cancer, intrahepatic and extrahepatic cholangiocarcinoma; this version's text concentrates on adjuvant chemotherapy and chemoradiation.
- What it means: NCCN is the source of the category grades quoted on the gallbladder cancer page; the adjuvant section leans on BILCAP for capecitabine and on SWOG S0809 for chemoradiation after margin-positive or node-positive resection.
- Caveats: The full guideline requires free registration on nccn.org; the JNCCN article is a summary.; Adjuvant recommendations for gallbladder cancer rest on subgroup and single-arm data.

## Sources

- JNCCN 2025: https://doi.org/10.6004/jnccn.2025.0042
- PubMed: https://pubmed.ncbi.nlm.nih.gov/40930144/
- NCCN Guidelines: Biliary Tract Cancers: https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1517

## Connected records

- collections: [NCCN Guidelines](https://onco.cc/collections/nccn/)
- cancers: [Biliary tract cancer (cholangiocarcinoma)](https://onco.cc/cancers/cholangiocarcinoma/), [Gallbladder cancer](https://onco.cc/cancers/gallbladder/)
- trials: [BILCAP](https://onco.cc/trials/bilcap/), [SWOG S0809](https://onco.cc/trials/swog-s0809/)
- journals: [Journal of the National Comprehensive Cancer Network](https://onco.cc/journals/jnccn/)

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