# Recurrent fusion of MYB and NFIB transcription factor genes in adenoid cystic carcinoma

Source: https://onco.cc/key-papers/paper-persson-myb-nfib-pnas-2009/  
OnCo record `paper-persson-myb-nfib-pnas-2009` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

This study discovered that adenoid cystic carcinomas of the salivary gland and breast are driven by a fusion of the MYB and NFIB genes, providing the defining molecular feature of the tumour and a diagnostic marker.

## Summary

Molecular study identifying a recurrent t(6;9) translocation in adenoid cystic carcinoma that fuses the MYB oncogene to NFIB, leading to MYB overexpression by loss of microRNA-mediated repression, present in the majority of tumours of both head and neck and breast origin.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: Proceedings of the National Academy of Sciences
- Year: 2009
- DOI: 10.1073/pnas.0909114106
- Authors: Persson M, Andrén Y, Mark J, et al.
- Findings: MYB-NFIB fusion detected in the majority of adenoid cystic carcinomas.; Fusion leads to MYB overexpression through loss of 3' untranslated region regulation.
- What it means: MYB immunostaining and MYB-NFIB fusion testing are now diagnostic tools for adenoid cystic carcinoma, and MYB is the principal target of therapeutic research in the disease.
- Caveats: No approved MYB-directed therapy has yet followed.

## Sources

- Proc Natl Acad Sci U S A 2009: https://doi.org/10.1073/pnas.0909114106
- PubMed: https://pubmed.ncbi.nlm.nih.gov/19841262/

## Connected records

- cancers: [Adenoid cystic carcinoma](https://onco.cc/cancers/adenoid-cystic-carcinoma/)
- journals: [Proceedings of the National Academy of Sciences](https://onco.cc/journals/pnas/)

---
JSON: https://onco.cc/api/v1/entities/paper-persson-myb-nfib-pnas-2009.json