# ROSELLA: relacorilant plus nab-paclitaxel in platinum-resistant ovarian cancer

Source: https://onco.cc/key-papers/paper-rosella-relacorilant-lancet-2025/  
OnCo record `paper-rosella-relacorilant-lancet-2025` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Adding relacorilant, a drug that blocks the cortisol receptor and thereby restores chemotherapy sensitivity, to nab-paclitaxel lengthened progression-free and overall survival in platinum-resistant ovarian cancer regardless of any biomarker.

## Summary

Phase 3 trial of 381 patients with platinum-resistant ovarian cancer and one to three prior lines randomised to intermittent relacorilant plus nab-paclitaxel or nab-paclitaxel alone.

Median progression-free survival was 6.54 versus 5.52 months (hazard ratio 0.70) and interim median overall survival 15.97 versus 11.50 months (hazard ratio 0.69), with a similar safety profile between arms.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: The Lancet
- Year: 2025
- DOI: 10.1016/S0140-6736(25)01040-2
- Authors: Olawaiye AB, Gladieff L, O'Malley DM, et al.
- Findings: Median progression-free survival 6.54 vs 5.52 months; hazard ratio 0.70.; Interim median overall survival 15.97 vs 11.50 months; hazard ratio 0.69.
- What it means: Relacorilant with nab-paclitaxel is a new option for platinum-resistant disease that does not depend on folate receptor status, with regulatory review following the trial.
- Caveats: Open-label design.; Overall survival analysis was interim.

## Sources

- Lancet 2025: https://doi.org/10.1016/S0140-6736(25)01040-2
- PubMed: https://pubmed.ncbi.nlm.nih.gov/40473448/

## Connected records

- cancers: [Platinum-resistant ovarian cancer](https://onco.cc/cancers/platinum-resistant-ovarian-cancer/)
- drugs: [Relacorilant](https://onco.cc/drugs/relacorilant/)
- trials: [ROSELLA / GOG-3073](https://onco.cc/trials/rosella/)
- journals: [The Lancet](https://onco.cc/journals/lancet/)

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