# From melanocytes to melanomas

Source: https://onco.cc/key-papers/paper-shain-nat-rev-cancer/  
OnCo record `paper-shain-nat-rev-cancer` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one pathway page, indexed on Europe PMC as PubMed record 27125352 and published in Nature Reviews Cancer; the citing page links this DOI, which is how the record was matched.

## Summary

Melanomas on sun-exposed skin are heterogeneous tumours, which can be subtyped on the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic neoplasm can also be staged by how far it has progressed, ranging from a benign neoplasm, such as a naevus, to a malignant neoplasm, such as a metastatic melanoma. Each subtype of melanoma can evolve through distinct evolutionary trajectories, passing through (or sometimes skipping over) various stages of transformation. This Review delineates several of the more common progression trajectories that occur in the patient setting and proposes models for tumour evolution that integrate genetic, histopathological, clinical and biological insights from the melanoma literature.

Indexed on Europe PMC as PubMed record 27125352 (DOI 10.1038/nrc.2016.37). Matched by DOI alone: one pathway page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Nature Reviews Cancer
- Year: 2016
- DOI: 10.1038/nrc.2016.37
- Authors: Shain AH, Bastian BC
- What it means: One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Nat Rev Cancer 2016: https://doi.org/10.1038/nrc.2016.37
- PubMed: https://pubmed.ncbi.nlm.nih.gov/27125352/
- Europe PMC: https://europepmc.org/article/MED/27125352

## Connected records

- pathways: [Melanoma (KEGG map)](https://onco.cc/pathways/melanoma-signalling/)
- journals: [Nature Reviews Cancer](https://onco.cc/journals/nature-reviews-cancer/)

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