# Theories of carcinogenesis: an emerging perspective

Source: https://onco.cc/key-papers/paper-sonnenschein-semin-cancer-biol/  
OnCo record `paper-sonnenschein-semin-cancer-biol` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one pathway page and one term page, indexed on Europe PMC as PubMed record 18472276 and published in Seminars in cancer biology; the citing pages link this DOI, which is how the record was matched.

## Summary

Four decades ago Leslie Foulds remarked that "Experimental analysis has produced an alarming mass of empirical facts without providing an adequate language for their communication or effective concepts for their synthesis". Examining the relevance of the data avalanche we all generate and are subjected to in the context of the premises and predictions of the current cancer theories may help resolve this paradox. This goal is becoming increasingly relevant given the looming attempts to rigorously model and parameterize crucial events in carcinogenesis (microenvironmental conditions, cellular proliferation and motility), which will require the adoption of reliable premises on which to base those efforts. This choice must be made a priori, as premises are not testable, and data are not free of the theoretical frame used to gather them. In this review we provide a critical analysis of the two main currents in cancer research, one centered at the cellular level of biological organization, the somatic mutation theory, which conceptualizes carcinogenesis as a problem of cell proliferation control, and the other centered at the tissue level, the tissue organization filed theory, which considers carcinogenesis a process akin to organogenesis gone awry.

Indexed on Europe PMC as PubMed record 18472276 (DOI 10.1016/j.semcancer.2008.03.012). Matched by DOI alone: one pathway page and one term page cite this DOI among their external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Seminars in cancer biology
- Year: 2008
- DOI: 10.1016/j.semcancer.2008.03.012
- Authors: Sonnenschein C, Soto AM
- What it means: One pathway page and one term page on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Semin Cancer Biol 2008: https://doi.org/10.1016/j.semcancer.2008.03.012
- PubMed: https://pubmed.ncbi.nlm.nih.gov/18472276/
- Europe PMC: https://europepmc.org/article/MED/18472276

## Connected records

- pathways: [Theories of cancer: how the ideas connect](https://onco.cc/pathways/theories-of-cancer/)
- terms: [Tissue organisation field theory (Sonnenschein and Soto)](https://onco.cc/terms/tissue-organisation-field-theory/)
- journals: [Seminars in cancer biology](https://onco.cc/journals/seminars-in-cancer-biology/)

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