# The cancer genome

Source: https://onco.cc/key-papers/paper-stratton-nature/  
OnCo record `paper-stratton-nature` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one term page, indexed on Europe PMC as PubMed record 19360079 and published in Nature; the citing page links this DOI, which is how the record was matched.

## Summary

All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of large numbers of cancer genomes. These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed.

Indexed on Europe PMC as PubMed record 19360079 (DOI 10.1038/nature07943). Matched by DOI alone: one term page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Nature
- Year: 2009
- DOI: 10.1038/nature07943
- Authors: Stratton MR, Campbell PJ, Futreal PA
- What it means: One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Nature 2009: https://doi.org/10.1038/nature07943
- PubMed: https://pubmed.ncbi.nlm.nih.gov/19360079/
- Europe PMC: https://europepmc.org/article/MED/19360079

## Connected records

- terms: [Driver and passenger mutations: the refined somatic mutation theory](https://onco.cc/terms/driver-passenger-model/)
- journals: [Nature](https://onco.cc/journals/nature/)

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