# Variability in patterns of recurrence after resection of primary retroperitoneal sarcoma (TARPSWG)

Source: https://onco.cc/key-papers/paper-tarpswg-retroperitoneal-sarcoma-gronchi-ann-surg-2016/  
OnCo record `paper-tarpswg-retroperitoneal-sarcoma-gronchi-ann-surg-2016` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Pooling over a thousand patients from eight expert centres showed that recurrence after retroperitoneal sarcoma surgery depends on histology: liposarcoma recurs locally, leiomyosarcoma spreads distantly, which shapes follow-up and the case for radiotherapy or chemotherapy by subtype.

## Summary

Retrospective analysis of 1,007 patients with primary retroperitoneal sarcoma treated with curative-intent surgery at eight Trans-Atlantic Retroperitoneal Sarcoma Working Group centres, describing patterns of local and distant recurrence and survival by histology.

Five-year overall survival was 67 percent; well-differentiated liposarcoma recurred locally with almost no metastases, dedifferentiated liposarcoma recurred both ways, and leiomyosarcoma had a high distant recurrence rate with low local recurrence.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: Annals of Surgery
- Year: 2016
- DOI: 10.1097/SLA.0000000000001447
- Authors: Gronchi A, Strauss DC, Miceli R, et al.
- Findings: Five-year overall survival 67 percent after complete resection.; Local recurrence dominant in liposarcoma; distant recurrence dominant in leiomyosarcoma.
- What it means: Histology-specific strategies, such as considering neoadjuvant chemotherapy for leiomyosarcoma and high-grade dedifferentiated liposarcoma in STRASS2, follow from these patterns.
- Caveats: Retrospective data from expert centres; results may not generalise to non-specialist surgery.

## Sources

- Ann Surg 2016: https://doi.org/10.1097/SLA.0000000000001447
- PubMed: https://pubmed.ncbi.nlm.nih.gov/26727100/

## Connected records

- cancers: [Retroperitoneal sarcoma](https://onco.cc/cancers/retroperitoneal-sarcoma/)

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