# Integrated genomic characterisation of endometrial carcinoma (The Cancer Genome Atlas)

Source: https://onco.cc/key-papers/paper-tcga-endometrial-nature-2013/  
OnCo record `paper-tcga-endometrial-nature-2013` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Sequencing of 373 endometrial cancers revealed four molecular groups, POLE ultramutated, microsatellite unstable, copy-number low and copy-number high, that cut across the traditional endometrioid and serous types and predict outcome.

## Summary

Integrated genomic, transcriptomic and proteomic analysis of 373 endometrial carcinomas by The Cancer Genome Atlas defining four groups: POLE ultramutated (with excellent outcome), microsatellite instability hypermutated, copy-number low (endometrioid) and copy-number high (serous-like, TP53-mutated, worst outcome); about a quarter of high-grade endometrioid tumours resembled serous carcinoma molecularly.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: Nature
- Year: 2013
- DOI: 10.1038/nature12113
- Authors: Cancer Genome Atlas Research Network, Kandoth C, Schultz N, et al.
- Findings: Four molecular subgroups with distinct progression-free survival.; 25 percent of high-grade endometrioid tumours had serous-like copy-number-high profiles.
- What it means: This is the origin of the molecular classification now used for every endometrial cancer, translated into a practical test by ProMisE.
- Caveats: Research-grade sequencing; clinical surrogates were needed for routine use.

## Sources

- Nature 2013: https://doi.org/10.1038/nature12113
- PubMed: https://pubmed.ncbi.nlm.nih.gov/23636398/

## Connected records

- cancers: [p53-abnormal endometrial cancer, including uterine serous carcinoma](https://onco.cc/cancers/endometrial-p53-abnormal/), [POLE-ultramutated endometrial cancer](https://onco.cc/cancers/endometrial-pole-ultramutated/)
- journals: [Nature](https://onco.cc/journals/nature/)

---
JSON: https://onco.cc/api/v1/entities/paper-tcga-endometrial-nature-2013.json