# Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol

Source: https://onco.cc/key-papers/paper-van-den-heuvel-eibrink-nat-rev-urol/  
OnCo record `paper-van-den-heuvel-eibrink-nat-rev-urol` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one cancer page, indexed on Europe PMC as PubMed record 29089605 and published in Nature reviews. Urology; the citing page links this DOI, which is how the record was matched.

## Summary

The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP-RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP-RTSG best available treatment standard.

Indexed on Europe PMC as PubMed record 29089605 (DOI 10.1038/nrurol.2017.163). Matched by DOI alone: one cancer page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Nature reviews. Urology
- Year: 2017
- DOI: 10.1038/nrurol.2017.163
- Authors: van den Heuvel-Eibrink MM, Hol JA, Pritchard-Jones K, et al.
- What it means: One cancer page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Nat Rev Urol 2017: https://doi.org/10.1038/nrurol.2017.163
- PubMed: https://pubmed.ncbi.nlm.nih.gov/29089605/
- Europe PMC: https://europepmc.org/article/MED/29089605

## Connected records

- cancers: [Wilms tumour (nephroblastoma)](https://onco.cc/cancers/wilms-tumor/)

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