# Expression of Small Noncoding RNAs in Urinary Exosomes Classifies Prostate Cancer into Indolent and Aggressive Disease

Source: https://onco.cc/key-papers/paper-wang-urinary-exosome-small-rna-prostate-j-urol-2020/  
OnCo record `paper-wang-urinary-exosome-small-rna-prostate-j-urol-2020` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The first report of a urine test reading small RNAs from vesicles to detect prostate cancer and judge its grade.

## Summary

Small non-coding RNAs from urinary exosomes of 235 participants were read on microarrays to build classifiers, which were then validated in a case-control sample of 1,436 subjects with 94 per cent sensitivity and 92 per cent specificity.

## Fields

- Kind: Key paper
- Last checked: 2026-11-04
- Journal: Journal of Urology
- Year: 2020
- DOI: 10.1097/ju.0000000000001020
- Authors: Wang WW, Sorokin I, Aleksic I, et al.
- Findings: Validation sensitivity 94%, specificity 92% (case-control).
- What it means: Promising, but case-control designs overstate accuracy compared with testing the people who would actually use it.
- Caveats: Case-control design.

## Sources

- Wang et al., J Urol 2020: https://doi.org/10.1097/ju.0000000000001020
- PubMed: https://pubmed.ncbi.nlm.nih.gov/32191585/

## Connected records

- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- fronts: [Diagnostics & Biomarkers](https://onco.cc/fronts/diagnostics/)
- technologies: [Liquid RNA biopsy (cell-free, vesicle and platelet RNA)](https://onco.cc/technologies/liquid-rna-biopsy/)
- drugs: [miR Sentinel](https://onco.cc/drugs/mir-sentinel/)
- terms: [Biomarker](https://onco.cc/terms/biomarker/)

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