# Aneuploidy acts both oncogenically and as a tumor suppressor

Source: https://onco.cc/key-papers/paper-weaver-cancer-cell/  
OnCo record `paper-weaver-cancer-cell` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one term page, indexed on Europe PMC as PubMed record 17189716 and published in Cancer Cell; the citing page links this DOI, which is how the record was matched.

## Summary

An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells. Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has remained untested due to the difficulty of selectively generating aneuploidy. Cells and mice with reduced levels of the mitosis-specific, centromere-linked motor protein CENP-E are now shown to develop aneuploidy and chromosomal instability in vitro and in vivo. An increased rate of aneuploidy does drive an elevated level of spontaneous lymphomas and lung tumors in aged animals. Remarkably, however, in examples of chemically or genetically induced tumor formation, an increased rate of aneuploidy is a more effective inhibitor than initiator of tumorigenesis. These findings reveal a role of aneuploidy and chromosomal instability in preventing tumorigenesis.

Indexed on Europe PMC as PubMed record 17189716 (DOI 10.1016/j.ccr.2006.12.003). Matched by DOI alone: one term page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Cancer Cell
- Year: 2007
- DOI: 10.1016/j.ccr.2006.12.003
- Authors: Weaver BA, Silk AD, Montagna C, et al.
- What it means: One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Cancer Cell 2007: https://doi.org/10.1016/j.ccr.2006.12.003
- PubMed: https://pubmed.ncbi.nlm.nih.gov/17189716/
- Europe PMC: https://europepmc.org/article/MED/17189716

## Connected records

- terms: [Aneuploidy and chromosomal instability as the cause of cancer](https://onco.cc/terms/aneuploidy-theory-of-cancer/)
- journals: [Cancer Cell](https://onco.cc/journals/cancer-cell/)

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