# WHO classification of tumours of the urinary system and male genital organs, 2022: renal, penile and testicular tumours

Source: https://onco.cc/key-papers/paper-who-2022-gu-moch-eur-urol-2022/  
OnCo record `paper-who-2022-gu-moch-eur-urol-2022` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The 2022 World Health Organization classification of kidney tumours reorganises renal cell carcinoma into morphologically and molecularly defined types, including new molecularly defined entities, and clarifies chromophobe, papillary and clear cell subtypes.

## Summary

Summary of the fifth-edition WHO classification for renal, penile and testicular tumours, introducing molecularly defined renal cell carcinomas (TFE3-rearranged, TFEB-altered, ELOC-mutated, fumarate hydratase-deficient, SDH-deficient, ALK-rearranged, SMARCB1-deficient medullary), abolishing type 1 and type 2 papillary subdivision, and refining eosinophilic and oncocytic tumours.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: European Urology
- Year: 2022
- DOI: 10.1016/j.eururo.2022.06.016
- Authors: Moch H, Amin MB, Berney DM, et al.
- What it means: Kidney cancer subtype pages use these definitions; several rare entities are now diagnosed by molecular testing rather than appearance alone.
- Caveats: Many new entities lack subtype-specific treatment evidence.

## Sources

- Eur Urol 2022: https://doi.org/10.1016/j.eururo.2022.06.016
- PubMed: https://pubmed.ncbi.nlm.nih.gov/35853783/

## Connected records

- cancers: [Chromophobe renal cell carcinoma](https://onco.cc/cancers/chromophobe-rcc/), [Clear cell renal cell carcinoma](https://onco.cc/cancers/clear-cell-rcc/), [Papillary renal cell carcinoma](https://onco.cc/cancers/papillary-rcc/)
- journals: [European Urology](https://onco.cc/journals/european-urology/)

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