# Regression of primary low-grade gastric MALT lymphoma after eradication of Helicobacter pylori

Source: https://onco.cc/key-papers/paper-wotherspoon-h-pylori-malt-lancet-1993/  
OnCo record `paper-wotherspoon-h-pylori-malt-lancet-1993` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

In six patients, eradicating the stomach bacterium Helicobacter pylori with antibiotics made low-grade gastric lymphoma regress, proving that a cancer could be caused by, and treated through, a chronic infection.

## Summary

Case series of six patients with primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type and Helicobacter pylori infection treated with antibiotics to eradicate the organism.

In five patients the lymphoma regressed histologically and endoscopically after eradication, supporting the hypothesis that the lymphoma is driven by antigenic stimulation from the infection.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: The Lancet
- Year: 1993
- DOI: 10.1016/0140-6736(93)91409-F
- Authors: Wotherspoon AC, Doglioni C, Diss TC, et al.
- Findings: Lymphoma regression in five of six patients after Helicobacter pylori eradication.
- What it means: Antibiotic eradication is the first-line treatment for Helicobacter pylori-positive gastric MALT lymphoma, curing most patients without chemotherapy or radiotherapy.
- Caveats: Six patients; lymphomas with t(11;18) or deep invasion often do not respond and need radiotherapy.

## Sources

- Lancet 1993: https://doi.org/10.1016/0140-6736(93)91409-F
- PubMed: https://pubmed.ncbi.nlm.nih.gov/8102719/

## Connected records

- cancers: [Marginal zone lymphoma](https://onco.cc/cancers/marginal-zone-lymphoma/)
- journals: [The Lancet](https://onco.cc/journals/lancet/)

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