# Cytoreductive surgery and HIPEC for malignant peritoneal mesothelioma: multi-institutional registry

Source: https://onco.cc/key-papers/paper-yan-peritoneal-mesothelioma-crs-hipec-jco-2009/  
OnCo record `paper-yan-peritoneal-mesothelioma-crs-hipec-jco-2009` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Pooling eight centres, this registry showed that removing all visible peritoneal mesothelioma and washing the abdomen with heated chemotherapy gave a median survival of over four years, transforming the outlook for selected patients.

## Summary

Retrospective multi-institutional registry of 405 patients with diffuse malignant peritoneal mesothelioma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy at eight specialised centres.

Median overall survival was 53 months with three- and five-year survival of 60 and 47 percent; epithelioid histology, absence of nodal metastases, completeness of cytoreduction and use of HIPEC were independently associated with survival, while perioperative mortality was 2 percent.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: Journal of Clinical Oncology
- Year: 2009
- DOI: 10.1200/JCO.2009.23.9640
- Authors: Yan TD, Deraco M, Baratti D, et al.
- Findings: Median overall survival 53 months; five-year survival 47 percent.; Completeness of cytoreduction and epithelioid subtype were the strongest prognostic factors.
- What it means: Cytoreductive surgery with HIPEC in an experienced centre is the standard for fit patients with resectable epithelioid peritoneal mesothelioma, a disease that had a median survival of about a year on chemotherapy alone.
- Caveats: Retrospective registry with selection of fit patients with resectable disease.; No randomised comparison with systemic therapy exists.

## Sources

- J Clin Oncol 2009: https://doi.org/10.1200/JCO.2009.23.9640
- PubMed: https://pubmed.ncbi.nlm.nih.gov/19917862/

## Connected records

- cancers: [Peritoneal mesothelioma](https://onco.cc/cancers/peritoneal-mesothelioma/)
- journals: [Journal of Clinical Oncology](https://onco.cc/journals/jco/)

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