# Endogenous T-Cell Therapy: Clinical Experience

Source: https://onco.cc/key-papers/paper-yee-endogenous-t-cell-therapy-cancer-j-2015/  
OnCo record `paper-yee-endogenous-t-cell-therapy-cancer-j-2015` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A review that names and describes endogenous T-cell therapy: growing the rare cancer-recognising T cells from a patient's blood and giving them back, as an alternative to tumour-derived or genetically engineered T cells.

## Summary

The review sets out three approaches to adoptive T-cell transfer (tumour-infiltrating lymphocytes, CAR- or TCR-engineered lymphocytes, and expansion of low-frequency endogenous T cells from peripheral blood) and describes the third, ETC therapy, its isolation and expansion methods and its clinical experience (Cancer Journal 2015).

## Fields

- Kind: Key paper
- Last checked: 2026-11-05
- Journal: The Cancer Journal
- Year: 2015
- DOI: 10.1097/PPO.0000000000000158
- Authors: Yee C, Lizee G, Schueneman AJ.
- Findings: Defines endogenous T-cell (ETC) therapy as the isolation and expansion of low-frequency tumour-reactive T cells from peripheral blood.; Argues that ETC trials can be started rapidly once a tumour-associated target epitope is identified, which could allow personalised antigen-specific T-cell therapy for almost any solid tumour.
- What it means: The paper gives the approach its name and makes the case for it beyond melanoma.
- Caveats: Narrative review by the method's developers.

## Sources

- DOI 10.1097/PPO.0000000000000158: https://doi.org/10.1097/PPO.0000000000000158
- PubMed 26588682: https://pubmed.ncbi.nlm.nih.gov/26588682/

## Connected records

- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)
- terms: [Endogenous T-cell therapy](https://onco.cc/terms/endogenous-t-cell-therapy/)
- people: [Cassian Yee](https://onco.cc/people/cassian-yee/)
- journals: [The cancer journal](https://onco.cc/journals/the-cancer-journal/)

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