# PAPPA2

Source: https://onco.cc/targets/pappa2/  
OnCo record `pappa2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PAPPA2 (Pappalysin-2) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.

## Summary

Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: pappalysin 2; Pappalysin-2; PAPPE; PAPP-A2; PLAC3
- Tags: cancer-genes-wave
- Symbol: PAPPA2
- Class: enzyme
- Biology: Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. Location: Secreted (UniProt). Locus 1q25.2 (HGNC).
- Where found: Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:14615: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14615
- UniProt Q9BXP8: https://www.uniprot.org/uniprotkb/Q9BXP8/entry
- NCBI Gene 60676: https://www.ncbi.nlm.nih.gov/gene/60676
- Ensembl ENSG00000116183: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116183

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

---
JSON: https://onco.cc/api/v1/entities/pappa2.json