# PAPSS1

Source: https://onco.cc/targets/papss1/  
OnCo record `papss1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PAPSS1 (Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.81, affected pathway 0.89, genetic association 0.39).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: 3'-phosphoadenosine 5'-phosphosulfate synthase 1; Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; ATPSK1; PAPSS
- Tags: cancer-genes-wave
- Symbol: PAPSS1
- Class: kinase
- Biology: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells. Locus 4q25 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8603: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8603
- UniProt O43252: https://www.uniprot.org/uniprotkb/O43252/entry
- NCBI Gene 9061: https://www.ncbi.nlm.nih.gov/gene/9061
- Ensembl ENSG00000138801: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138801

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/papss1.json