# PARP3

Source: https://onco.cc/targets/parp3/  
OnCo record `parp3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PARP3 (Protein mono-ADP-ribosyltransferase PARP3) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Ovarian cancer and Prostate cancer.

## Summary

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.00, clinical 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: poly(ADP-ribose) polymerase family member 3; Protein mono-ADP-ribosyltransferase PARP3; ADPRT3; IRT1; hPARP-3; pADPRT-3; ARTD3; ADPRTL3
- Tags: cancer-genes-wave
- Symbol: PARP3
- Class: enzyme
- Biology: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signalling pathway leading to the reparation of DNA strand breaks. Involved in single-strand break repair by catalysing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA. Location: Nucleus; Chromosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (UniProt). Locus 3p21.2 (HGNC).
- Where found: Ovarian cancer: Open Targets association 0.59 with ovarian cancer (MONDO_0008170); Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.98; UniProt keyword "DNA repair". Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:273: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:273
- UniProt Q9Y6F1: https://www.uniprot.org/uniprotkb/Q9Y6F1/entry
- NCBI Gene 10039: https://www.ncbi.nlm.nih.gov/gene/10039
- Ensembl ENSG00000041880: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000041880

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/parp3.json