# PARP4

Source: https://onco.cc/targets/parp4/  
OnCo record `parp4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PARP4 (Protein mono-ADP-ribosyltransferase PARP4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Multiple myeloma and Non-small-cell lung cancer.

## Summary

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction.

IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma, Lung Adenocarcinoma, Plasma Cell Myeloma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: poly(ADP-ribose) polymerase family member 4; Protein mono-ADP-ribosyltransferase PARP4; VAULT3; p193; VPARP; VWA5C; ARTD4; ADPRTL1
- Tags: cancer-genes-wave
- Symbol: PARP4
- Class: oncogene
- Biology: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction. Location: Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 13q12.12 (HGNC).
- Where found: Colorectal cancer: IntOGen driver in 1 cohort (COADREAD); Multiple myeloma: IntOGen driver in 1 cohort (PCM); Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:271: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:271
- UniProt Q9UKK3: https://www.uniprot.org/uniprotkb/Q9UKK3/entry
- NCBI Gene 143: https://www.ncbi.nlm.nih.gov/gene/143
- Ensembl ENSG00000102699: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000102699

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/parp4.json