# PARTIQoL

Source: https://onco.cc/trials/partiqol/  
OnCo record `partiqol` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A randomised trial of protons versus IMRT for localised prostate cancer, built to see whether protons cause less bowel and bladder harm at the same cancer control.

## Summary

PARTIQoL (NCT01617161) randomises men with low- or intermediate-risk localised prostate cancer to proton beam therapy or intensity-modulated photon radiotherapy, with bowel quality of life among the leading endpoints. It is one of the few adult proton-versus-photon trials that can test whether a distal LET and RBE difference near rectum and bladder is clinically real. Accrual has been slow in a field where patients can obtain protons off-trial. ClinicalTrials.gov listed the study as active, not recruiting, with primary completion in December 2025; the primary readout is not yet in the corpus.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-17
- Tags: radiation-wave5
- Registry id: NCT01617161
- Phase: 3
- Setting: Low- and intermediate-risk localised prostate cancer: proton beam therapy versus intensity-modulated photon radiotherapy
- Sponsor: Massachusetts General Hospital

## Sources

- ClinicalTrials.gov NCT01617161: https://clinicaltrials.gov/study/NCT01617161

## Connected records

- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Proton therapy](https://onco.cc/technologies/proton-therapy/)
- institutions: [Massachusetts General Hospital Cancer Center](https://onco.cc/institutions/mgh/)
- terms: [Alpha/beta ratio](https://onco.cc/terms/alpha-beta-ratio/), [Bragg peak](https://onco.cc/terms/bragg-peak/), [Linear energy transfer (LET)](https://onco.cc/terms/linear-energy-transfer/), [Relative biological effectiveness (RBE)](https://onco.cc/terms/relative-biological-effectiveness/)
- pairings: [Caution: proton therapy vs IMRT](https://onco.cc/pairings/proton-vs-imrt/)
- ideas: [Pooled coverage-with-evidence for proton therapy across all centres](https://onco.cc/ideas/idea-fund-proton-coverage-with-evidence/), [Use LET, RBE and alpha/beta to decide when protons beat IMRT](https://onco.cc/ideas/idea-bio2-let-rbe-ab-selects-protons/)

---
JSON: https://onco.cc/api/v1/entities/partiqol.json