# PATZ1

Source: https://onco.cc/targets/patz1/  
OnCo record `patz1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PATZ1 (POZ-, AT hook-, and zinc finger-containing protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Colorectal cancer.

## Summary

Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis. Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: POZ/BTB and AT hook containing zinc finger 1; POZ-, AT hook-, and zinc finger-containing protein 1; dJ400N23; ZBTB19; ZNF278
- Tags: cancer-genes-wave
- Symbol: PATZ1
- Class: transcription
- Biology: Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis. Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53. Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions. Location: Nucleus (UniProt). Locus 22q12.2 (HGNC).
- Where found: Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898); Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13071: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13071
- UniProt Q9HBE1: https://www.uniprot.org/uniprotkb/Q9HBE1/entry
- NCBI Gene 23598: https://www.ncbi.nlm.nih.gov/gene/23598
- Ensembl ENSG00000100105: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100105

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/patz1.json