# PAX7

Source: https://onco.cc/targets/pax7/  
OnCo record `pax7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PAX7 (Paired box protein Pax-7) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Rhabdomyosarcoma.

## Summary

Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.

Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.93, genetic association 0.43, somatic mutation 0.97, animal model 0.56).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: paired box 7; Paired box protein Pax-7; Hup1
- Tags: cancer-genes-wave
- Symbol: PAX7
- Class: transcription
- Biology: Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. Location: Nucleus (UniProt). Locus 1p36.13 (HGNC).
- Where found: Sarcomas: Open Targets association 0.71 with sarcoma (MONDO_0005089); Rhabdomyosarcoma: Open Targets association 0.68 with rhabdomyosarcoma (MONDO_0005212)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8621: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8621
- UniProt P23759: https://www.uniprot.org/uniprotkb/P23759/entry
- NCBI Gene 5081: https://www.ncbi.nlm.nih.gov/gene/5081
- Ensembl ENSG00000009709: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000009709

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Rhabdomyosarcoma](https://onco.cc/cancers/rhabdomyosarcoma/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/pax7.json