# PAX8

Source: https://onco.cc/targets/pax8/  
OnCo record `pax8` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PAX8 (Paired box protein Pax-8) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.

## Summary

Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes affected pathway 0.37, literature 0.99, genetic association 0.50, somatic mutation 0.95, animal model 0.53).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: paired box 8; Paired box protein Pax-8; PAX-8
- Tags: cancer-genes-wave
- Symbol: PAX8
- Class: transcription
- Biology: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Location: Nucleus (UniProt). Locus 2q14.1 (HGNC).
- Where found: Thyroid cancer: Open Targets association 0.61 with thyroid cancer (MONDO_0002108)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Female Reproductive Organ Cancer.

## Sources

- HGNC HGNC:8622: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8622
- UniProt Q06710: https://www.uniprot.org/uniprotkb/Q06710/entry
- NCBI Gene 7849: https://www.ncbi.nlm.nih.gov/gene/7849
- Ensembl ENSG00000125618: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125618

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Thyroid cancer](https://onco.cc/cancers/thyroid/)

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JSON: https://onco.cc/api/v1/entities/pax8.json