# PAX9

Source: https://onco.cc/targets/pax9/  
OnCo record `pax9` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PAX9 (Paired box protein Pax-9) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.85, animal model 0.48, genetic association 0.65).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: paired box 9; Paired box protein Pax-9
- Tags: cancer-genes-wave
- Symbol: PAX9
- Class: transcription
- Biology: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. Location: Nucleus (UniProt). Locus 14q13.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8623: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8623
- UniProt P55771: https://www.uniprot.org/uniprotkb/P55771/entry
- NCBI Gene 5083: https://www.ncbi.nlm.nih.gov/gene/5083
- Ensembl ENSG00000198807: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198807

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/pax9.json