# PBK

Source: https://onco.cc/targets/pbk/  
OnCo record `pbk` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PBK (Lymphokine-activated killer T-cell-originated protein kinase) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.

## Summary

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells.

CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Gefitinib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: PDZ binding kinase; Lymphokine-activated killer T-cell-originated protein kinase; FLJ14385; Nori-3; CT84
- Tags: cancer-genes-wave
- Symbol: PBK
- Class: kinase
- Biology: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilisation and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Locus 8p21.1 (HGNC).
- Where found: Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease; Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18282: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18282
- UniProt Q96KB5: https://www.uniprot.org/uniprotkb/Q96KB5/entry
- NCBI Gene 55872: https://www.ncbi.nlm.nih.gov/gene/55872
- Ensembl ENSG00000168078: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168078

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/pbk.json