# PCM1

Source: https://onco.cc/targets/pcm1/  
OnCo record `pcm1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PCM1 (Pericentriolar material 1 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.

## Summary

Required for centrosome assembly and function. Essential for the correct localisation of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.46, somatic mutation 0.74). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Glioblastoma Multiforme.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: pericentriolar material 1; Pericentriolar material 1 protein; PTC4
- Tags: cancer-genes-wave
- Symbol: PCM1
- Class: tumor-suppressor
- Biology: Required for centrosome assembly and function. Essential for the correct localisation of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites. Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites. Location: Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasmic granule; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite (UniProt). Locus 8p22 (HGNC).
- Where found: Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8727: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8727
- UniProt Q15154: https://www.uniprot.org/uniprotkb/Q15154/entry
- NCBI Gene 5108: https://www.ncbi.nlm.nih.gov/gene/5108
- Ensembl ENSG00000078674: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078674

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)

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JSON: https://onco.cc/api/v1/entities/pcm1.json