# PCNX2

Source: https://onco.cc/targets/pcnx2/  
OnCo record `pcnx2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PCNX2 (Pecanex-like protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H).

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.63, animal model 0.52, genetic association 0.64).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: pecanex 2; Pecanex-like protein 2; KIAA0435; FLJ11383; PCNXL2
- Tags: cancer-genes-wave
- Symbol: PCNX2
- Class: other
- Biology: May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Location: Membrane (UniProt). Locus 1q42.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8736: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8736
- UniProt A6NKB5: https://www.uniprot.org/uniprotkb/A6NKB5/entry
- NCBI Gene 80003: https://www.ncbi.nlm.nih.gov/gene/80003
- Ensembl ENSG00000135749: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135749

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/pcnx2.json