# PDCD4

Source: https://onco.cc/targets/pdcd4/  
OnCo record `pdcd4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PDCD4 (Programmed cell death protein 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer.

## Summary

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: programmed cell death 4; Programmed cell death protein 4; H731
- Tags: cancer-genes-wave
- Symbol: PDCD4
- Class: other
- Biology: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Location: Nucleus; Cytoplasm (UniProt). Locus 10q25.2 (HGNC).
- Where found: Lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8763: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8763
- UniProt Q53EL6: https://www.uniprot.org/uniprotkb/Q53EL6/entry
- NCBI Gene 27250: https://www.ncbi.nlm.nih.gov/gene/27250
- Ensembl ENSG00000150593: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000150593

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/)

---
JSON: https://onco.cc/api/v1/entities/pdcd4.json